ABSTRACT Introduction: Remote ischemic preconditioning (RIPC) is a new noninvasive myocardial protection strategy that uses blood pressure cuf inflation to simulate transient non-fatal ischemia to protect the myocardium and reduce ischemia-reperfusion injury. Sulfonylureas may mask the effects of RIPC due to their cardioprotec-tive effect. This meta-analysis aimed to evaluate whether RIPC, in the absence of sulfonylureas, reduces troponin release in patients undergoing cardiac surgery. Methods: We conducted a meta-analysis of randomized controlled clinical trials to determine whether RIPC can reduce postoperative troponin release in cardiac surgery patients undergoing cardiopulmonary bypass without treatment with sulfonylureas. The data were normalized to equivalent units prior to the analysis. A random-effects model was used to provide more conservative estimate of the effects in the presence of known or unknown heterogeneity. Results: Six studies with a total of 570 participants were included. The analysis showed that troponin release was lower in the RIPC group than in the control group at six hours (test of standardized mean differences = 0, Z=3.64, P<0.001) and 48 hours (Z=2.72, P=0.007) postoperatively. When the mean of cross-clamping time was > 60 minutes, RIPC reduced troponin release at six hours (Z=2.84, P=0.005), 24 hours (Z=2.64, P=0.008), and 48 hours (Z=2.87, P=0.004) postoperatively. Conclusion: In cardiac surgery patients who are not taking sulfonylureas, RIPC can reduce troponin release at six and 48 hours postoperatively; hence, RIPC may serve significant benefits in certain cardiac surgery patients.

Abstract In this study, the effects of degradation on ascorbic acid (AA) in asparagus-lemon juice with different blending ratios were investigated during storage. The R2 values of the first-order kinetic model for predicting AA loss were 0.8216-0.9990, indicating that the model described well the degradation of AA in asparagus-lemon juice with different blending ratios. Response surface methodology (RSM) was applied to optimize the blending ratio of asparagus-lemon juice during storage. The optimum blending ratios that selected by the RSM were: 23%, 26%, 27%, 28% and 29% of diluted asparagus juice blended with 85% of diluted lemon juice, and the desirability were 0.820. The RSM correlation coefficients (R2) between experimental and model predicted values ranged from 0.6394 to 0.9975. Therefore, RSM and the first-order model may be effective tools to optimize the blending ratio of blended juice and AA degradation in juices.

ABSTRACT Introduction: Remote ischemic preconditioning (RIPC) is a new noninvasive myocardial protection strategy that uses blood pressure cuf inflation to simulate transient non-fatal ischemia to protect the myocardium and reduce ischemia-reperfusion injury. Sulfonylureas may mask the effects of RIPC due to their cardioprotec-tive effect. This meta-analysis aimed to evaluate whether RIPC, in the absence of sulfonylureas, reduces troponin release in patients undergoing cardiac surgery. Methods: We conducted a meta-analysis of randomized controlled clinical trials to determine whether RIPC can reduce postoperative troponin release in cardiac surgery patients undergoing cardiopulmonary bypass without treatment with sulfonylureas. The data were normalized to equivalent units prior to the analysis. A random-effects model was used to provide more conservative estimate of the effects in the presence of known or unknown heterogeneity. Results: Six studies with a total of 570 participants were included. The analysis showed that troponin release was lower in the RIPC group than in the control group at six hours (test of standardized mean differences = 0, Z=3.64, P<0.001) and 48 hours (Z=2.72, P=0.007) postoperatively. When the mean of cross-clamping time was > 60 minutes, RIPC reduced troponin release at six hours (Z=2.84, P=0.005), 24 hours (Z=2.64, P=0.008), and 48 hours (Z=2.87, P=0.004) postoperatively. Conclusion: In cardiac surgery patients who are not taking sulfonylureas, RIPC can reduce troponin release at six and 48 hours postoperatively; hence, RIPC may serve significant benefits in certain cardiac surgery patients.

ABSTRACT Two-stage harvesting is the main method for performing the mechanized harvesting of peanuts, and the picking device is a core part of the combined harvester in China. In order to solve the problem of pod loss caused by the "stacking", "impact" and "throwing up" of peanut plants by a traditional cam-slide spring-finger cylinder picking device, the shovel-finger and cylinder peanut-picking device was developed and used in a picking-up performance test based on the study of peanut-plant strip-picking characteristics. The mathematical model of the mechanism was established by analyzing the structure of the mechanism and the peanut-plant strip-picking characteristics, and the parameters of the mechanism were optimized using the objective function method. The prototype was developed and tested. The experiments in which the prototype was used to collect peanut plants indicated that the phenomenon of peanut plants being stacked and thrown disappeared. Through a response surface analysis and prototype test, the optimal working parameters of the picking device were obtained: the forward speed V was 48.0 m/minute, the rotational speed N was 45.3 r/minute and the ground height H was -18 mm. The peanut-plant picking rate was 98.9% and the fruit loss rate was 2.8% under two different harvesting conditions for which the peanut-plant moisture content was 15~17%.

Nossa pesquisa focou-se nas principais características de planejamento e de desempenho de liberação cólon-específica tempo-dependente (TDCS) de comprimidos, que leva em conta a constância relativa observada no tempo de trânsito intestinal das formas de dosagem. A doença inflamatória do intestino (IBD) pode afetar o tempo de trânsito e, geralmente, resulta em fezes aquosas. Comparando ao TDCS e a comprimidos TDCS com matriz-cerosa, investigou-se sistema promissor de liberação cólon-específica tempo-dependente. Em nosso estudo, avaliou-se comprimido revestido com matriz base de supositório. A base de supositório solúvel em água auxilia a expansão do comprimido, facilita a dissolução uniforme do filme e atinge alta pressão osmótica. Associando a expansão do carboximetil amido sódico (CMS-Na) à absorção de umidade do NaCl, o comprimido revestido TDCS originou sistema de liberação direcionado e de erupção. Observou-se correlação muito boa entre a liberação in vitro e a in vivo do fármaco. Este comprimido revestido TDCS representa estratégia promissora para o controle da liberação do fármaco na região gastrintestinal mais baixa.

Our research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms. But inflammatory bowel disease（IBD）can affect the transit time, and usually results in watery stool. Compared to the TDCS and wax-matrix TDCS tablet, a promising time-dependent colon-specific delivery system was investigated. In our study, a suppository-base-matrix coated tablet was evaluated. Water soluble suppository-base helps the expansion of tablet, facilitates uniform film dissolution and achives high osmotic pressure. Combining the expansion of carboxymethyl starch sodium (CMS-Na) and the moisture absorption of NaCl, the coated TDCS tablet obtained a burst and targeted drug delivery system. A very good correlation between in vitro drug release and in vivo outcome was observed. This TDCS coated tablet provides a promising strategy to control drug release to the desired lower gastrointestinal region.

Um método de indexação de semeamento bidireccional (dual-way seeds indexing - DWSI), baseado em árvore-R e no modelo simples de característica de Consórcio Geoespacial Aberto (Open Geospatial Consortium - OGC), foi proposto para solucionar o problema de alastramento de intersecção de polígonos. O algoritmo de união paralela de polígono baseado no método DWSI melhorado e o modelo paralela de programação OpenMP foi desenvolvido para validar a usabilidade do método de partição de dados. Os resultados experimentais revelaram que o método DWSI melhorado pode implementar uma partição paralela de tarefas robustas, superando o problema de alastramento de intersecção de polígonos. O algoritmo de união paralela aplicado ao DWSI não apenas levou o processamento de dados a uma escala maior, como também acelerou a computação em comparação com a proposta serial, demonstrando uma maior eficiência computacional com referências de aceleração mais altas no tratamento de conjuntos de dados em larga-escala. Portanto, o método DWSI melhorado pode ser uma abordagem potencial para a paralelização e otimização dos algoritmos de sobreposição de dados de vetor baseados no modelo de dados simples OGC no nível de camada de característica.

A dual-way seeds indexing (DWSI) method based on R-tree and the Open Geospatial Consortium (OGC) simple feature model was proposed to solve the polygon intersection-spreading problem. The parallel polygon union algorithm based on the improved DWSI and the OpenMP parallel programming model was developed to validate the usability of the data partition method. The experimental results reveal that the improved DWSI method can implement a robust parallel task partition by overcoming the polygon intersection-spreading problem. The parallel union algorithm applied DWSI not only scaled up the data processing but also speeded up the computation compared with the serial proposal, and it showed a higher computational efficiency with higher speedup benchmarks in the treatment of larger-scale dataset. Therefore, the improved DWSI can be a potential approach to parallelizing the vector data overlay algorithms based on the OGC simple data model at the feature layer level.